mc-ASTRA (mc_astra, commonly imported as mca) provides a bridge between single-cell data analysis workflows from scverse, factor-based models from MOFA-FLEX, and prior knowledge to generate tissue-centric descriptions from single-cell data.
This package facilitates the implementation of Multicellular Factor Analysis by providing functions to process and format single-cell data into a multi-view format, together with additional visualization and downstream tasks to analyse and interpret multicellular programs.
You need to have Python 3.12 or newer installed on your system. If you don't have Python installed, we recommend installing uv.
mc-ASTRA currently targets the development version of MOFA-FLEX.
mc-ASTRA is currently pre-1.0. APIs may change between minor versions.
The 0.1.x series introduces a revised API and is not fully backward-compatible with 0.0.x.
Install mc-ASTRA from PyPI with:
pip install mc-astraOr install the latest development version:
pip install git+https://github.com/saezlab/mc-astra.git@mainImport the package as:
import mc_astra as mcaRicardo Omar Ramirez Flores, Jan David Lanzer, Daniel Dimitrov, Britta Velten, Julio Saez-Rodriguez (2023) Multicellular factor analysis of single-cell data for a tissue-centric understanding of disease eLife 12:e93161