diff --git a/src/jsc/event_loop.rs b/src/jsc/event_loop.rs
index be5c9fe4a5a3..f464d1773b35 100644
--- a/src/jsc/event_loop.rs
+++ b/src/jsc/event_loop.rs
@@ -191,6 +191,8 @@ unsafe extern "Rust" {
     /// `WTFTimer::run` — `timer` is an erased `*mut bun_runtime::timer::WTFTimer`.
     /// Defined in `bun_runtime::dispatch`. Link-time resolved.
     fn __bun_run_wtf_timer(timer: *mut (), vm: *mut VirtualMachine);
+    /// `timer::All::has_due_regular_timer`. Defined in `bun_runtime::dispatch`.
+    safe fn __bun_has_due_timer() -> bool;
     /// Tag-specific shutdown release for a queued-but-never-run task. Called
     /// from `release_queued_tasks_for_shutdown` (after `shutdown_for_exit`,
     /// before `destructOnExit`) for every entry left in `self.tasks`.
@@ -455,6 +457,24 @@ impl EventLoop {
         let _ = self.tick_concurrent_with_count();
     }
 
+    /// Mid-tick re-drain: the ref-count/signal/GC maintenance always runs;
+    /// only the `concurrent_tasks` pop is skipped when a `setImmediate` is
+    /// pending or a JS timer is due, so `tick()` returns and `auto_tick*`
+    /// can run them (Node interleaves timers/check between thread-pool
+    /// completion batches). `immediate_tasks` is same-thread and checked
+    /// first so a late cross-thread push cannot slip ahead of it; the
+    /// `concurrent_tasks` guard keeps the clock read off the path when
+    /// nothing arrived.
+    fn tick_concurrent_unless_due(&mut self) {
+        self.tick_concurrent_maintenance();
+        if !self.immediate_tasks.is_empty()
+            || (!self.concurrent_tasks.is_empty() && __bun_has_due_timer())
+        {
+            return;
+        }
+        let _ = self.tick_concurrent_pop_batch();
+    }
+
     /// Check whether refConcurrently has been called but the change has not yet been applied to the
     /// underlying event loop's `active` counter
     pub fn has_pending_refs(&self) -> bool {
@@ -474,7 +494,7 @@ impl EventLoop {
         }
     }
 
-    pub fn tick_concurrent_with_count(&mut self) -> usize {
+    fn tick_concurrent_maintenance(&mut self) {
         self.update_counts();
 
         #[cfg(unix)]
@@ -489,7 +509,14 @@ impl EventLoop {
         }
 
         self.run_imminent_gc_timer();
+    }
+
+    pub fn tick_concurrent_with_count(&mut self) -> usize {
+        self.tick_concurrent_maintenance();
+        self.tick_concurrent_pop_batch()
+    }
 
+    fn tick_concurrent_pop_batch(&mut self) -> usize {
         let concurrent = self.concurrent_tasks.pop_batch();
         let count = concurrent.count;
         if count == 0 {
@@ -620,7 +647,7 @@ impl EventLoop {
 
         loop {
             while self.tick_with_count(ctx) > 0 {
-                self.tick_concurrent();
+                self.tick_concurrent_unless_due();
                 self.global_ref().handle_rejected_promises();
             }
             if self
@@ -631,7 +658,7 @@ impl EventLoop {
                 self.entered_event_loop_count -= 1;
                 return;
             }
-            self.tick_concurrent();
+            self.tick_concurrent_unless_due();
             if self.tasks.readable_length() > 0 {
                 continue;
             }
@@ -639,7 +666,7 @@ impl EventLoop {
         }
 
         while self.tick_with_count(ctx) > 0 {
-            self.tick_concurrent();
+            self.tick_concurrent_unless_due();
         }
 
         self.global_ref().handle_rejected_promises();
diff --git a/src/runtime/dispatch.rs b/src/runtime/dispatch.rs
index 3dbffa4cb078..31a29a22c069 100644
--- a/src/runtime/dispatch.rs
+++ b/src/runtime/dispatch.rs
@@ -878,6 +878,19 @@ unsafe fn __bun_cancel_pending_immediate(
     }
 }
 
+/// Declared `extern "Rust"` in `bun_jsc::event_loop`; `tick()`'s mid-tick
+/// yield check.
+#[unsafe(no_mangle)]
+fn __bun_has_due_timer() -> bool {
+    let all = crate::jsc_hooks::timer_all();
+    if all.is_null() {
+        return false;
+    }
+    // SAFETY: `all` is the live per-thread `All`; single JS thread, and
+    // `has_due_regular_timer` only peeks (no heap mutation, no JS re-entry).
+    unsafe { (*all).has_due_regular_timer() }
+}
+
 /// `__bun_run_wtf_timer` body — cast the low-tier erased `*mut ()` to the real
 /// `crate::timer::WTFTimer` and fire it.
 ///
diff --git a/src/runtime/timer/mod.rs b/src/runtime/timer/mod.rs
index fc4cb96665e4..d70ffb806816 100644
--- a/src/runtime/timer/mod.rs
+++ b/src/runtime/timer/mod.rs
@@ -1013,6 +1013,21 @@ impl All {
         }
     }
 
+    /// `EventLoop::tick()`'s mid-tick yield probe. WTF timers are skipped to
+    /// avoid the `wtf_timers` lock; they drain at the next `get_timeout`.
+    pub(crate) fn has_due_regular_timer(&self) -> bool {
+        let Some(timer) = self.timers.peek() else {
+            return false;
+        };
+        // SAFETY: `peek` returns a live heap node.
+        let next = unsafe { &(*timer).next };
+        let next = Timespec {
+            sec: next.sec,
+            nsec: next.nsec,
+        };
+        !next.greater(&Timespec::now(TimespecMockMode::ForceRealTime))
+    }
+
     /// Pop the next due timer. `now` is filled lazily on first call so we
     /// don't pay for `clock_gettime` when the heap is empty.
     fn next(&mut self, has_set_now: &mut bool, now: &mut Timespec) -> Option<*mut EventLoopTimer> {
diff --git a/test/js/node/timers/node-timers.test.ts b/test/js/node/timers/node-timers.test.ts
index 5ba41145a5af..f2f1e2cba226 100644
--- a/test/js/node/timers/node-timers.test.ts
+++ b/test/js/node/timers/node-timers.test.ts
@@ -245,3 +245,70 @@ describe.each(["with", "without"])("setImmediate %s timers running", mode => {
 it("should defer microtasks when an exception is thrown in an immediate", async () => {
   expect(await bunRun(["run", path.join(import.meta.dir, "timers-immediate-exception-fixture.js")])).toSpawn();
 });
+
+test("chained thread-pool callbacks yield to due timers", async () => {
+  // crypto.pbkdf2 completes via enqueue_task_concurrent on every platform
+  // (fs.read on Windows goes through libuv's callback and would not exercise
+  // the mid-tick re-drain path).
+  const script = `
+    const crypto = require('crypto');
+    let order = '';
+    setInterval(() => { order += 'T'; }, 1).unref();
+    setTimeout(() => {
+      (function go(i) {
+        if (i >= 20) {
+          const runs = order.match(/R+/g) || [];
+          const maxRun = Math.max(0, ...runs.map(r => r.length));
+          console.log(JSON.stringify({ order, maxRun }));
+          process.exit(0);
+        }
+        crypto.pbkdf2('a', 'b', 1, 8, 'sha256', () => {
+          order += 'R';
+          go(i + 1);
+        });
+        // Spin so the 1ms interval is overdue and the thread-pool job has
+        // landed before the mid-tick re-drain decision.
+        const s = Date.now(); while (Date.now() - s < 3);
+      })(0);
+    }, 5);
+  `;
+  await using proc = Bun.spawn({
+    cmd: [bunExe(), "-e", script],
+    env: bunEnv,
+    stderr: "pipe",
+  });
+  const [stdout, stderr, exitCode] = await Promise.all([proc.stdout.text(), proc.stderr.text(), proc.exited]);
+  expect(stderr).toBe("");
+  const out = JSON.parse(stdout.trim());
+  // Due timers must break the chain every iteration; allow small jitter.
+  expect({ maxRunAtMost3: out.maxRun <= 3, order: out.order }).toEqual({ maxRunAtMost3: true, order: out.order });
+  expect(exitCode).toBe(0);
+});
+
+test("chained thread-pool callbacks yield to pending setImmediate", async () => {
+  const script = `
+    const crypto = require('crypto');
+    let order = '';
+    setTimeout(() => {
+      (function go(i) {
+        if (i >= 20) { console.log(JSON.stringify({ order })); process.exit(0); }
+        crypto.pbkdf2('a', 'b', 1, 8, 'sha256', () => {
+          order += 'R';
+          if (i === 0) setImmediate(() => { order += 'I'; });
+          go(i + 1);
+        });
+        const s = Date.now(); while (Date.now() - s < 3);
+      })(0);
+    }, 1);
+  `;
+  await using proc = Bun.spawn({
+    cmd: [bunExe(), "-e", script],
+    env: bunEnv,
+    stderr: "pipe",
+  });
+  const [stdout, stderr, exitCode] = await Promise.all([proc.stdout.text(), proc.stderr.text(), proc.exited]);
+  expect(stderr).toBe("");
+  const out = JSON.parse(stdout.trim());
+  expect(out.order.slice(0, 2)).toBe("RI");
+  expect(exitCode).toBe(0);
+});