diff --git a/ci-operator/config/openshift/release/openshift-release-main__nightly-4.22.yaml b/ci-operator/config/openshift/release/openshift-release-main__nightly-4.22.yaml
index cf3591ba62d2e..da11865127070 100644
--- a/ci-operator/config/openshift/release/openshift-release-main__nightly-4.22.yaml
+++ b/ci-operator/config/openshift/release/openshift-release-main__nightly-4.22.yaml
@@ -2026,6 +2026,62 @@ tests:
         WORKER_MEMORY=24576
       TEST_SUITE: openshift/conformance/parallel
     workflow: agent-e2e-generic-conformance
+- as: e2e-agent-compact-iso-no-registry
+  capabilities:
+  - intranet
+  cron: 0 2/8 * * *
+  steps:
+    cluster_profile: equinix-ocp-metal
+    env:
+      DEVSCRIPTS_CONFIG: |
+        AGENT_E2E_TEST_SCENARIO=COMPACT_IPV4
+        AGENT_E2E_TEST_BOOT_MODE=ISO_NO_REGISTRY
+        AGENT_CLEANUP_ISO_BUILDER_CACHE_LOCAL_DEV=true
+        FEATURE_SET=TechPreviewNoUpgrade
+    workflow: agent-e2e-generic-conformance-iso-no-registry
+- as: e2e-agent-ha-dualstack-iso-no-registry
+  capabilities:
+  - intranet
+  cron: 30 2/8 * * *
+  steps:
+    cluster_profile: equinix-ocp-metal
+    env:
+      DEVSCRIPTS_CONFIG: |
+        AGENT_E2E_TEST_SCENARIO=HA_IPV4V6
+        AGENT_E2E_TEST_BOOT_MODE=ISO_NO_REGISTRY
+        AGENT_CLEANUP_ISO_BUILDER_CACHE_LOCAL_DEV=true
+        FEATURE_SET=TechPreviewNoUpgrade
+    workflow: agent-e2e-generic-conformance-iso-no-registry
+  timeout: 4h0m0s
+- as: e2e-agent-ha5-dualstack-iso-no-registry
+  capabilities:
+  - intranet
+  cron: 0 3/8 * * *
+  steps:
+    cluster_profile: equinix-ocp-metal
+    env:
+      DEVSCRIPTS_CONFIG: |
+        AGENT_E2E_TEST_SCENARIO=5CONTROL_IPV4V6
+        AGENT_E2E_TEST_BOOT_MODE=ISO_NO_REGISTRY
+        AGENT_CLEANUP_ISO_BUILDER_CACHE_LOCAL_DEV=true
+        FEATURE_SET=TechPreviewNoUpgrade
+    workflow: agent-e2e-generic-conformance-iso-no-registry
+  timeout: 4h0m0s
+- as: e2e-agent-sno-ipv4-iso-no-registry
+  capabilities:
+  - intranet
+  cron: 30 3/8 * * *
+  node_architecture: amd64
+  steps:
+    cluster_profile: equinix-ocp-metal
+    env:
+      DEVSCRIPTS_CONFIG: |
+        AGENT_E2E_TEST_SCENARIO=SNO_IPV4
+        AGENT_E2E_TEST_BOOT_MODE=ISO_NO_REGISTRY
+        AGENT_CLEANUP_ISO_BUILDER_CACHE_LOCAL_DEV=true
+        AGENT_PLATFORM_TYPE=none
+        FEATURE_SET=TechPreviewNoUpgrade
+    workflow: agent-e2e-generic-conformance-iso-no-registry
 - as: e2e-metal-ovn-sno-cert-rotation-suspend-30d
   cron: 0 8 * * Fri
   steps:
diff --git a/ci-operator/jobs/openshift/release/openshift-release-main-periodics.yaml b/ci-operator/jobs/openshift/release/openshift-release-main-periodics.yaml
index 29e3fce5d036b..198834c89292a 100644
--- a/ci-operator/jobs/openshift/release/openshift-release-main-periodics.yaml
+++ b/ci-operator/jobs/openshift/release/openshift-release-main-periodics.yaml
@@ -207421,6 +207421,91 @@ periodics:
     - name: result-aggregator
       secret:
         secretName: result-aggregator
+- agent: kubernetes
+  cluster: build10
+  cron: 0 2/8 * * *
+  decorate: true
+  decoration_config:
+    skip_cloning: true
+  extra_refs:
+  - base_ref: main
+    org: openshift
+    repo: release
+  labels:
+    capability/intranet: intranet
+    ci-operator.openshift.io/cloud: equinix-ocp-metal
+    ci-operator.openshift.io/cloud-cluster-profile: equinix-ocp-metal
+    ci-operator.openshift.io/variant: nightly-4.22
+    ci.openshift.io/generator: prowgen
+    ci.openshift.io/no-builds: "true"
+    job-release: "4.22"
+    pj-rehearse.openshift.io/can-be-rehearsed: "true"
+  name: periodic-ci-openshift-release-main-nightly-4.22-e2e-agent-compact-iso-no-registry
+  spec:
+    containers:
+    - args:
+      - --gcs-upload-secret=/secrets/gcs/service-account.json
+      - --image-import-pull-secret=/etc/pull-secret/.dockerconfigjson
+      - --lease-server-credentials-file=/etc/boskos/credentials
+      - --report-credentials-file=/etc/report/credentials
+      - --secret-dir=/secrets/ci-pull-credentials
+      - --target=e2e-agent-compact-iso-no-registry
+      - --variant=nightly-4.22
+      command:
+      - ci-operator
+      env:
+      - name: HTTP_SERVER_IP
+        valueFrom:
+          fieldRef:
+            fieldPath: status.podIP
+      image: quay-proxy.ci.openshift.org/openshift/ci:ci_ci-operator_latest
+      imagePullPolicy: Always
+      name: ""
+      ports:
+      - containerPort: 8080
+        name: http
+      resources:
+        requests:
+          cpu: 10m
+      volumeMounts:
+      - mountPath: /etc/boskos
+        name: boskos
+        readOnly: true
+      - mountPath: /secrets/ci-pull-credentials
+        name: ci-pull-credentials
+        readOnly: true
+      - mountPath: /secrets/gcs
+        name: gcs-credentials
+        readOnly: true
+      - mountPath: /secrets/manifest-tool
+        name: manifest-tool-local-pusher
+        readOnly: true
+      - mountPath: /etc/pull-secret
+        name: pull-secret
+        readOnly: true
+      - mountPath: /etc/report
+        name: result-aggregator
+        readOnly: true
+    serviceAccountName: ci-operator
+    volumes:
+    - name: boskos
+      secret:
+        items:
+        - key: credentials
+          path: credentials
+        secretName: boskos-credentials
+    - name: ci-pull-credentials
+      secret:
+        secretName: ci-pull-credentials
+    - name: manifest-tool-local-pusher
+      secret:
+        secretName: manifest-tool-local-pusher
+    - name: pull-secret
+      secret:
+        secretName: registry-pull-credentials
+    - name: result-aggregator
+      secret:
+        secretName: result-aggregator
 - agent: kubernetes
   cluster: build10
   cron: 0 */12 * * *
@@ -207506,6 +207591,178 @@ periodics:
     - name: result-aggregator
       secret:
         secretName: result-aggregator
+- agent: kubernetes
+  cluster: build10
+  cron: 30 2/8 * * *
+  decorate: true
+  decoration_config:
+    skip_cloning: true
+    timeout: 4h0m0s
+  extra_refs:
+  - base_ref: main
+    org: openshift
+    repo: release
+  labels:
+    capability/intranet: intranet
+    ci-operator.openshift.io/cloud: equinix-ocp-metal
+    ci-operator.openshift.io/cloud-cluster-profile: equinix-ocp-metal
+    ci-operator.openshift.io/variant: nightly-4.22
+    ci.openshift.io/generator: prowgen
+    ci.openshift.io/no-builds: "true"
+    job-release: "4.22"
+    pj-rehearse.openshift.io/can-be-rehearsed: "true"
+  name: periodic-ci-openshift-release-main-nightly-4.22-e2e-agent-ha-dualstack-iso-no-registry
+  spec:
+    containers:
+    - args:
+      - --gcs-upload-secret=/secrets/gcs/service-account.json
+      - --image-import-pull-secret=/etc/pull-secret/.dockerconfigjson
+      - --lease-server-credentials-file=/etc/boskos/credentials
+      - --report-credentials-file=/etc/report/credentials
+      - --secret-dir=/secrets/ci-pull-credentials
+      - --target=e2e-agent-ha-dualstack-iso-no-registry
+      - --variant=nightly-4.22
+      command:
+      - ci-operator
+      env:
+      - name: HTTP_SERVER_IP
+        valueFrom:
+          fieldRef:
+            fieldPath: status.podIP
+      image: quay-proxy.ci.openshift.org/openshift/ci:ci_ci-operator_latest
+      imagePullPolicy: Always
+      name: ""
+      ports:
+      - containerPort: 8080
+        name: http
+      resources:
+        requests:
+          cpu: 10m
+      volumeMounts:
+      - mountPath: /etc/boskos
+        name: boskos
+        readOnly: true
+      - mountPath: /secrets/ci-pull-credentials
+        name: ci-pull-credentials
+        readOnly: true
+      - mountPath: /secrets/gcs
+        name: gcs-credentials
+        readOnly: true
+      - mountPath: /secrets/manifest-tool
+        name: manifest-tool-local-pusher
+        readOnly: true
+      - mountPath: /etc/pull-secret
+        name: pull-secret
+        readOnly: true
+      - mountPath: /etc/report
+        name: result-aggregator
+        readOnly: true
+    serviceAccountName: ci-operator
+    volumes:
+    - name: boskos
+      secret:
+        items:
+        - key: credentials
+          path: credentials
+        secretName: boskos-credentials
+    - name: ci-pull-credentials
+      secret:
+        secretName: ci-pull-credentials
+    - name: manifest-tool-local-pusher
+      secret:
+        secretName: manifest-tool-local-pusher
+    - name: pull-secret
+      secret:
+        secretName: registry-pull-credentials
+    - name: result-aggregator
+      secret:
+        secretName: result-aggregator
+- agent: kubernetes
+  cluster: build10
+  cron: 0 3/8 * * *
+  decorate: true
+  decoration_config:
+    skip_cloning: true
+    timeout: 4h0m0s
+  extra_refs:
+  - base_ref: main
+    org: openshift
+    repo: release
+  labels:
+    capability/intranet: intranet
+    ci-operator.openshift.io/cloud: equinix-ocp-metal
+    ci-operator.openshift.io/cloud-cluster-profile: equinix-ocp-metal
+    ci-operator.openshift.io/variant: nightly-4.22
+    ci.openshift.io/generator: prowgen
+    ci.openshift.io/no-builds: "true"
+    job-release: "4.22"
+    pj-rehearse.openshift.io/can-be-rehearsed: "true"
+  name: periodic-ci-openshift-release-main-nightly-4.22-e2e-agent-ha5-dualstack-iso-no-registry
+  spec:
+    containers:
+    - args:
+      - --gcs-upload-secret=/secrets/gcs/service-account.json
+      - --image-import-pull-secret=/etc/pull-secret/.dockerconfigjson
+      - --lease-server-credentials-file=/etc/boskos/credentials
+      - --report-credentials-file=/etc/report/credentials
+      - --secret-dir=/secrets/ci-pull-credentials
+      - --target=e2e-agent-ha5-dualstack-iso-no-registry
+      - --variant=nightly-4.22
+      command:
+      - ci-operator
+      env:
+      - name: HTTP_SERVER_IP
+        valueFrom:
+          fieldRef:
+            fieldPath: status.podIP
+      image: quay-proxy.ci.openshift.org/openshift/ci:ci_ci-operator_latest
+      imagePullPolicy: Always
+      name: ""
+      ports:
+      - containerPort: 8080
+        name: http
+      resources:
+        requests:
+          cpu: 10m
+      volumeMounts:
+      - mountPath: /etc/boskos
+        name: boskos
+        readOnly: true
+      - mountPath: /secrets/ci-pull-credentials
+        name: ci-pull-credentials
+        readOnly: true
+      - mountPath: /secrets/gcs
+        name: gcs-credentials
+        readOnly: true
+      - mountPath: /secrets/manifest-tool
+        name: manifest-tool-local-pusher
+        readOnly: true
+      - mountPath: /etc/pull-secret
+        name: pull-secret
+        readOnly: true
+      - mountPath: /etc/report
+        name: result-aggregator
+        readOnly: true
+    serviceAccountName: ci-operator
+    volumes:
+    - name: boskos
+      secret:
+        items:
+        - key: credentials
+          path: credentials
+        secretName: boskos-credentials
+    - name: ci-pull-credentials
+      secret:
+        secretName: ci-pull-credentials
+    - name: manifest-tool-local-pusher
+      secret:
+        secretName: manifest-tool-local-pusher
+    - name: pull-secret
+      secret:
+        secretName: registry-pull-credentials
+    - name: result-aggregator
+      secret:
+        secretName: result-aggregator
 - agent: kubernetes
   cluster: build09
   cron: 18 22 * * *
@@ -208355,6 +208612,92 @@ periodics:
     - name: result-aggregator
       secret:
         secretName: result-aggregator
+- agent: kubernetes
+  cluster: build10
+  cron: 30 3/8 * * *
+  decorate: true
+  decoration_config:
+    skip_cloning: true
+  extra_refs:
+  - base_ref: main
+    org: openshift
+    repo: release
+  labels:
+    capability/amd64: amd64
+    capability/intranet: intranet
+    ci-operator.openshift.io/cloud: equinix-ocp-metal
+    ci-operator.openshift.io/cloud-cluster-profile: equinix-ocp-metal
+    ci-operator.openshift.io/variant: nightly-4.22
+    ci.openshift.io/generator: prowgen
+    ci.openshift.io/no-builds: "true"
+    job-release: "4.22"
+    pj-rehearse.openshift.io/can-be-rehearsed: "true"
+  name: periodic-ci-openshift-release-main-nightly-4.22-e2e-agent-sno-ipv4-iso-no-registry
+  spec:
+    containers:
+    - args:
+      - --gcs-upload-secret=/secrets/gcs/service-account.json
+      - --image-import-pull-secret=/etc/pull-secret/.dockerconfigjson
+      - --lease-server-credentials-file=/etc/boskos/credentials
+      - --report-credentials-file=/etc/report/credentials
+      - --secret-dir=/secrets/ci-pull-credentials
+      - --target=e2e-agent-sno-ipv4-iso-no-registry
+      - --variant=nightly-4.22
+      command:
+      - ci-operator
+      env:
+      - name: HTTP_SERVER_IP
+        valueFrom:
+          fieldRef:
+            fieldPath: status.podIP
+      image: quay-proxy.ci.openshift.org/openshift/ci:ci_ci-operator_latest
+      imagePullPolicy: Always
+      name: ""
+      ports:
+      - containerPort: 8080
+        name: http
+      resources:
+        requests:
+          cpu: 10m
+      volumeMounts:
+      - mountPath: /etc/boskos
+        name: boskos
+        readOnly: true
+      - mountPath: /secrets/ci-pull-credentials
+        name: ci-pull-credentials
+        readOnly: true
+      - mountPath: /secrets/gcs
+        name: gcs-credentials
+        readOnly: true
+      - mountPath: /secrets/manifest-tool
+        name: manifest-tool-local-pusher
+        readOnly: true
+      - mountPath: /etc/pull-secret
+        name: pull-secret
+        readOnly: true
+      - mountPath: /etc/report
+        name: result-aggregator
+        readOnly: true
+    serviceAccountName: ci-operator
+    volumes:
+    - name: boskos
+      secret:
+        items:
+        - key: credentials
+          path: credentials
+        secretName: boskos-credentials
+    - name: ci-pull-credentials
+      secret:
+        secretName: ci-pull-credentials
+    - name: manifest-tool-local-pusher
+      secret:
+        secretName: manifest-tool-local-pusher
+    - name: pull-secret
+      secret:
+        secretName: registry-pull-credentials
+    - name: result-aggregator
+      secret:
+        secretName: result-aggregator
 - agent: kubernetes
   cluster: build09
   cron: '@weekly'