diff --git a/edx_repo_tools/__init__.py b/edx_repo_tools/__init__.py
index ce1305bf..70397087 100644
--- a/edx_repo_tools/__init__.py
+++ b/edx_repo_tools/__init__.py
@@ -1 +1 @@
-__version__ = "4.0.0"
+__version__ = "4.1.0"
diff --git a/edx_repo_tools/find_dependencies/find_python_dependencies.py b/edx_repo_tools/find_dependencies/find_python_dependencies.py
index 902f4e26..8f596826 100644
--- a/edx_repo_tools/find_dependencies/find_python_dependencies.py
+++ b/edx_repo_tools/find_dependencies/find_python_dependencies.py
@@ -8,6 +8,7 @@
 import os
 import requirements
 import sys
+import tomllib
 from pathlib import Path
 import requests
 
@@ -20,9 +21,9 @@ def request_package_info_url(package):
         if response.status_code == 200:
             data_dict = response.json()
             info = data_dict["info"]
-            return info["home_page"]            
+            return info["home_page"]
         else:
-            print(f"Failed to retrieve data for package {package}. Status code:", response.status_code)    
+            print(f"Failed to retrieve data for package {package}. Status code:", response.status_code)
 
 FIRST_PARTY_ORGS = ["openedx"]
 
@@ -42,14 +43,47 @@ def urls_in_orgs(urls, orgs):
         if any(f"/{org}/" in url for org in orgs)
     )
 
+
+def _names_from_uv_lock(data):
+    """
+    Yield package names from a uv.lock's fully-resolved [[package]] list.
+    This covers the same direct+transitive dependency closure that a
+    pip-compile'd requirements.txt used to represent.
+    """
+    for package in data.get("package", []):
+        name = package.get("name")
+        if name:
+            yield name
+
+
+def iter_requirement_names(path):
+    """
+    Yield package names declared in `path`, which may be a pip-compile style
+    requirements.txt or a uv.lock. Both represent a fully-resolved
+    direct+transitive dependency closure. A pyproject.toml is deliberately
+    not supported here: [project.dependencies]/[dependency-groups] only list
+    direct dependencies, so scanning it would silently miss transitive ones
+    and misleadingly suggest this tool resolves dependencies, which it does
+    not.
+    """
+    path = Path(path)
+    if path.name == "uv.lock":
+        yield from _names_from_uv_lock(tomllib.loads(path.read_text()))
+    else:
+        with open(path) as freq:
+            for req in requirements.parse(freq):
+                yield req.name
+
+
 @click.command()
 @click.option(
     '--req-file', 'directories',
     multiple=True,
     required=True,
-    help="The absolute file paths to locate Python dependencies" 
-        "within a particular repository. You can provide this "
-        "option multiple times to include multiple requirement files.",
+    help="The absolute file paths to locate Python dependencies "
+        "within a particular repository. Accepts pip-compile style "
+        "requirements.txt files or uv.lock. You can "
+        "provide this option multiple times to include multiple files.",
 )
 @click.option(
     '--ignore', 'ignore_paths',
@@ -60,16 +94,15 @@ def urls_in_orgs(urls, orgs):
 
 def main(directories=None, ignore_paths=None):
     """
-    Analyze the requirements in input directory mentioned on the command line.    
+    Analyze the requirements in input directory mentioned on the command line.
     """
 
     home_page = set()
     for directory in directories:
-        with open(directory) as fbase:
-            for req in requirements.parse(fbase):
-                url = request_package_info_url(req.name)
-                if url is not None:
-                    home_page.add(url)
+        for name in set(iter_requirement_names(directory)):
+            url = request_package_info_url(name)
+            if url is not None:
+                home_page.add(url)
 
     packages_urls = set(urls_in_orgs(home_page, SECOND_PARTY_ORGS))
 
diff --git a/tests/test_find_python_dependencies.py b/tests/test_find_python_dependencies.py
new file mode 100644
index 00000000..49cd9528
--- /dev/null
+++ b/tests/test_find_python_dependencies.py
@@ -0,0 +1,66 @@
+from unittest.mock import patch
+
+from edx_repo_tools.find_dependencies.find_python_dependencies import (
+    iter_requirement_names,
+    main,
+)
+
+
+def test_iter_requirement_names_requirements_txt(tmp_path):
+    req_file = tmp_path / "base.txt"
+    req_file.write_text(
+        "Django==4.2.1\n"
+        "git+https://github.com/mitodl/edx-sga.git@abc123#egg=edx-sga\n"
+    )
+    assert sorted(iter_requirement_names(req_file)) == ["Django", "edx-sga"]
+
+
+def test_iter_requirement_names_uv_lock(tmp_path):
+    uv_lock = tmp_path / "uv.lock"
+    uv_lock.write_text(
+        """
+        version = 1
+
+        [[package]]
+        name = "lxml"
+        version = "5.3.2"
+
+        [[package]]
+        name = "edx-sga"
+        version = "0.1"
+        """
+    )
+    assert sorted(iter_requirement_names(uv_lock)) == ["edx-sga", "lxml"]
+
+
+def test_main_flags_second_party_dependency_from_uv_lock(tmp_path):
+    uv_lock = tmp_path / "uv.lock"
+    uv_lock.write_text(
+        """
+        version = 1
+
+        [[package]]
+        name = "edx-sga"
+        version = "0.1"
+
+        [[package]]
+        name = "django"
+        version = "4.2.1"
+        """
+    )
+
+    def fake_request_package_info_url(package):
+        return {
+            "edx-sga": "https://github.com/mitodl/edx-sga",
+            "django": "https://github.com/django/django",
+        }.get(package)
+
+    with patch(
+        "edx_repo_tools.find_dependencies.find_python_dependencies.request_package_info_url",
+        side_effect=fake_request_package_info_url,
+    ):
+        with patch(
+            "edx_repo_tools.find_dependencies.find_python_dependencies.exit"
+        ) as mock_exit:
+            main.callback(directories=[str(uv_lock)], ignore_paths=[])
+            mock_exit.assert_called_once_with(1)